Discovery Communications will take control of its

first_imgDiscovery Communications will take control of its joint venture kids channel The Hub by the end of the year, according to a report in The Wall Street Journal.The report suggests Discovery and toy form Hasbro will rework their JV so that the cable giant takes a majority stake and rebrands the channel as Discovery Family.As the name suggests, the net’s output will move move towards family entertainment, with shows targeted at parents as well as kids.Hasbro would still control programming for six hours a day, between 09:00 and 15:00, according to the report, which cites unnamed sources close to the negotiations. Talks are said to be ongoing, but no deal has yet been struck.Earlier this year, The Hub’s president and CEO Margaret Loesch announced she was exiting the business at the end of 2014, which appears to fit with the time scale for the rebrand.No successor was announced, and The WSJ reported that Discovery group president for Discovery’s group president of Investigation Discovery, Destination America and the American Heroes Channel Henry Schleiff will add the new channel to its responsibilities.Discovery and Hasbro launched the channel more than four years ago, but have found going tough with kids TV cable market leaders Disney Channel, Nickelodeon and Cartoon Network the clear market leaders.The Hub’s biggest show is My Little Pony, and also runs series including Transformers, Adventure Camp and Flight 29 Down. Discovery is also rebadging Discovery Fit & Health as Discovery Life Channel in January next year.last_img read more

Russian researchers develop novel combined action drug for cancer diagnostics and treatment

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Dec 4 2018Russian researchers announced the development of a combined action drug based on ionizing radiation and bacterial toxin. Their total effect appeared to be 2,200 times stronger compared to that exerted by the radiation and toxin, separately. The drug affects tumor cells selectively providing better diagnostics and treatment of malignant tumors. These advances were reported in an article published in the Proceedings of the National Academy of Sciences.Chemotherapy is widely used for treatment of cancerous diseases. However, it is associated with severe side effects (hair loss, nausea, loss of appetite, oedema, anemia, memory disorders, and so on) as the drugs affect the body in total and are accumulated throughout normal tissues. Moreover, the chemotherapy often requires repeated drug administration to overcome tumor propensity to relapse. A perfect anti-cancer drug should provide a powerful impact to all tumor cells at once to prevent their recovery.The combined therapy proposed and realized by the Russian scientists appeared to be successful. “Just like modern armies deploy tanks, foot troops, and artillery, we also fight tumors using several mechanisms at once: ionizing radiation and a strong toxin of bacterial origin,” says Andrey Zvyagin, head of the Department of Biomedical Engineering at the Institute of Molecular Medicine, Sechenov University.The drug developed by the scientists consists of a nanoparticles, as the core, with embedded radiopharmaceutical agent (a source of ionizing beta-radiation), and a highly toxic toxin derived from bacterium Pseudomonas aeruginosa. The nanosized drug core is decorated with polymer to render the nanocomplex water miscible and biologically amiable and coupled with biological molecules, which represent the toxin fused with a targeting biomolecule by genetic engineering methods. The radiopharmaceutical agent is well secluded inside the nanoparticle and guarantees its side-effect-free targeted action to tumor cells. Blood vessels that feed the tumor have pores through which the drug enters the tumor from the blood flow. The targeting biomolecule binds itself with cancer cells causing them to accumulate in the primary and metastatic tumors. The radiopharmaceutical agent is able to affect the cells both in immediate proximity to the nanoparticles and up to 1 cm from them, providing for efficient therapy of considerable tumor masses. The toxin blocks the synthesis of proteins in the cells preventing them from restoration and dissemination.The new drug was tested both on cells and laboratory animals: breast cancer (the most widely spread type of cancer in women) was grafted on a laboratory mouse, and after that the tested drug was administered to it. In experiments on cells, the effect of the combination was 2,200 times stronger than the effect from the separate use of its components. The efficiency of combined therapy was confirmed by experiments on laboratory mice. The drug not only treats, but also facilitates visualization of the tumors, which makes it a diagnostical tool. The area of medicine that combines diagnostics and treatment is called theranostics. Source:https://www.sechenov.ru/last_img read more

Arsenic in drinking water may lead to thickening of the hearts main

first_img“The stronger association in subjects with elevated blood pressure suggests that individuals with pre-clinical heart disease might be more prone to the toxic effects of arsenic on the heart,” said Gernot Pichler, MD, PhD, and medical specialist for Internal Medicine, Department of Cardiology at Hospital Hietzing/Heart Center Clinic Floridsdorf in Vienna, Austria, and a visiting scholar in the Department of Environmental Health Sciences at Columbia University Mailman School of Public Health.Although this study was performed in tribal populations in the north, central and southwestern United States, the results are likely to be generalizable to millions of people in other rural locations exposed to low or moderate levels of arsenic in their water. The study also had only one measure of arsenic exposure and did not include long-term follow-up of the participants.”The study raises the question of whether the changes in heart structure are reversible if exposure is reduced. Some changes have occurred in water sources in the study communities, and it will be important to check the potential health impact of reducing arsenic exposure,” Pichler said.”Observational studies like this one are critical since cardiovascular disease remains the single leading cause of adult premature death worldwide and millions of individuals globally are exposed to arsenic and other metal contaminants,” noted Navas-Acien. Reviewed by Alina Shrourou, B.Sc. (Editor)May 8 2019Drinking water that is contaminated with arsenic may lead to thickening of the heart’s main pumping chamber in young adults, according to a new study by researchers at Columbia University Mailman School of Public Health. This structural change increases the risk for future heart problems. The findings are published online in Circulation: Cardiovascular Imaging, an American Heart Association journal.The researchers reviewed data from the Strong Heart Family Study, a study evaluating cardiovascular risk factors among young American Indian adults from Oklahoma, Arizona and North and South Dakota. Arsenic exposure was measured in urine samples from 1,337 adults (average age 30.7 years, 61 percent female) and the size, shape and function of their hearts were assessed using ultrasound (echocardiography). None of the participants had diabetes or heart disease at the start of the five-year study.”People drinking water from private wells, which are not regulated, need to be aware that arsenic may increase the risk for cardiovascular disease. Testing those wells is a critical first step to take action and prevent exposure,” said Ana Navas-Acien, PhD, professor of Environmental Health Sciences at Columbia Mailman School, and senior author.People are most frequently exposed to arsenic, a toxic metal, through drinking water in areas where groundwater is contaminated, including many American Indian tribal communities and other rural and suburban communities in the United States. Previously, several studies have shown that arsenic exposure raises the risk of heart disease and its risk factors, including high blood pressure and diabetes. This is the first study to review the question in young adults.Overall, arsenic exposure was higher than in the general United States population, but lower than that found in other studies conducted in Mexico and Bangladesh. With a two-fold increase in arsenic in the urine, the researchers found:Related StoriesRNA-binding protein SRSF3 appears to be key factor for proper heart contraction, survivalCutting around 300 calories a day protects the heart even in svelte adultsRepurposing a heart drug could increase survival rate of children with ependymoma 47 percent greater chance of thickening of the heart’s main pumping chamber (left ventricle) in the group as a whole; and 58 percent greater chance of thickening of the left ventricle in participants with increased or high blood pressure (blood pressure at least 120/80 mm Hg or using pressure-lowering medication) Source:https://www.mailman.columbia.edu/last_img read more

Ghosn case rattles Japans expat business community

first_img © 2019 AFP “This certainly has a negative effect on the ability of companies to attract top talent to Japan,” Schulz told AFP.As the Ghosn case has laid bare, Japan’s legal system gives enormous power to prosecutors, who nearly always secure guilty verdicts.Courts routinely allow suspects to be held for questioning for lengthy periods, and many major media outlets are largely supportive of the authorities.”People are worried. It creates a legal uncertainty on the business conditions in Japan,” said another Tokyo-based source with close ties to foreign firms. “Seeing how the system works, and how it is orchestrated in the media, creates anxiety among business leaders, an uneasy feeling,” the person said. Some in the expat business community believe the French-Brazilian-Lebanese tycoon, the once-revered chairman of Nissan, has been the victim of unfair harshness because he is a foreigner.”The way Mr. Ghosn is treated seems completely out of proportion compared to the way Japanese executives are treated,” said one Tokyo-based French businessperson, who asked not to be named.This businessperson pointed to a series of massive accounting scandals at Toshiba during which Japanese executives avoided criminal charges.In contrast, Ghosn has languished in a Tokyo detention centre for more than 50 days as he fights a string of allegations of financial misconduct. The court has banned his family from visiting, allowing only contact with his lawyers and diplomats.”It gives the impression of double standards, as if (Ghosn) was being treated this way because he is a foreigner. I do not see how they are going to attract qualified foreigners,” the person told AFP.”Ghosn was an icon, a symbol of French success and this has poured cold water on quite a few ambitions from young trainees—at least those training for careers in business and management.” Former Nissan chief Carlos Ghosn is fighting a string of allegations of financial misconduct Ghosn’s case has highlighted how the Japanese system differs from western business norms, analysts say Ghosn’s case has also highlighted how the Japanese system differs from western business norms, said corporate compliance lawyer Nobuo Gohara, also a former Tokyo prosecutor.Gohara noted that Nissan’s sitting Chief Executive Officer Hiroto Saikawa did not give Ghosn the opportunity to defend himself internally to the company’s board.Instead, the Nissan management conducted an internal probe, sided with prosecutors and swiftly sacked Ghosn after his arrest.”People see what kind of case this is, and what kind of treatment Mr. Ghosn has received so far,” Gohara told AFP.”If you were a manager with a very high salary in Japan—and because of your compensation, you might find yourself in a situation like that—I would imagine people with normal, common sense would not want to work in Japan,” he said.”You would be too scared.” Ghosn dominates talk in expat business circles Japan court rejects Ghosn release bid The detained executive was initially kept in a tiny room with Japanese-style tatami for sleeping—sparking outrage from abroad. He has now been moved to a larger room and has a Western-style bed, according to his lawyer Motonari Otsuru.But even Otsuru has dampened expectations his client could be released any time soon, suggesting it could be six months until a trial and stressing that bail is unlikely in such cases.’People are worried’Many in Japan have voiced surprise that foreigners have criticised their legal system and prosecutors have reacted angrily, saying they are playing by the rules in place.”This is a specific case,” said Seiji Nakata, head of Daiwa Securities. “I am in contact with foreign bosses and they have not voiced any pessimism on the subject”.But Ghosn dominates talk in expat business circles and while foreign investors are not yet rushing to leave Tokyo, the case has worried executives who fear they may unknowingly face legal troubles even if they think they are operating legally. Explore further The detained executive was initially kept in a tiny room with Japanese-style tatami for sleeping—sparking outrage from abroad Citation: Ghosn case rattles Japan’s expat business community (2019, January 10) retrieved 17 July 2019 from https://phys.org/news/2019-01-ghosn-case-rattles-japan-expat.html “Mr. Ghosn’s case has shone a strong spotlight on the opaqueness of Japan’s prosecution system,” said Martin Schulz, economist at the Fujitsu Research Institute in Tokyo. Carlos Ghosn’s prolonged detention under what critics see as Japan’s opaque and draconian legal system has alarmed foreign executives and sparked questions over the country’s ability to attract overseas talent. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Gadkari to lay foundation for roads fisheries jetty in coastal KarnatakaGadkari to

first_imgevents February 28, 2019 SHARE SHARE EMAIL Karnataka Infrastructure and Construction Mangaluru-Karkala road to be widened Published on Nitin Gadkari, Union Minister for Road Transport and Highways, Shipping and Water Resources, will soon lay the foundation stone for three road projects and a fisheries jetty in coastal Karnataka by videoconference. Nalin Kumar Kateel, Member of Parliament from Dakshina Kannada, told media persons in Mangaluru on Thursday after conducting a review meeting with the officials of the National Highways Authority of India that the projects include the widening of the national highway between Mangaluru in Dakshina Kannada district and Karkala in Udupi district into a four-lane road. Apart from this, two road projects will be taken up in Dakshina Kannada district under the Bharatmala programme. Gadkari will also lay the foundation stone for a fisheries jetty project under the Sagarmala programme. The fisheries jetty will be constructed at Kulai in Mangaluru taluk at a cost of ₹193 crore. Fishermen from the region have been urging the government to take up this project for the past five decades, Kateel said. Projects in progress Various other road projects are in progress in the Dakshina Kannada district. A high-level meeting has been conducted by the officials of the Union Ministry of Road Transport and Highways to speed up the work on a few stretches of the National Highway connecting Talapady bordering Kerala with Kundapura in Udupi district.Though most of the work has been completed, two flyovers in Mangaluru taluk are yet to be completed. The high-level meeting has given a timeframe to the contractor for the completion of these works, he added. SHARE COMMENT COMMENTSlast_img read more