Rae Sremmurd Enlist The Weeknd Future On New Album SR3MM

first_img Twitter https://twitter.com/RaeSremmurd/status/990983373089853440 Inside Rae Sremmurd’s Ambitious Triple Album rae-sremmurd-enlist-weeknd-future-new-album-sr3mm Email Rae Sremmurd Enlist The Weeknd, Future On New Album ‘SR3MM’ Facebook News The duo’s new triple album includes high-profile features plus solo efforts from both Slim Jxmmi and Swae LeeNate HertweckGRAMMYs May 3, 2018 – 8:59 am On May 4, Rae Sremmurd will drop their third album with a little something extra. The triple album, SR3MM, includes solo efforts JXMTRO by Slim Jxmmi and SWAECATION by Swae Lee as well as guest appearances across the three albums from the likes of The Weeknd, Future, Travis Scott, Juicy J, Young Thug, and Pharrell Williams. While several songs from the project have already been unleashed, including “CLOSE” featuring Scott, “Powerglide” with Juicy J, and “Chanel,” which comes from JXMTRO and features Williams and Lee, the news of The Weeknd, Future, and Young Thug gives fans a lot to look forward to tomorrow.The duo explained the differences between their solo albums to Rolling Stone, with Lee saying, “My side is crazy melodic,” and Jxmmi revealing he wasn’t as comfortable singing as his brother, so he “came out spraying” for his solo effort.Rae Sremmurd will hit the road later this year, opening the first 14 dates of GRAMMY winner Childish Gambino’s fall tour starting Sept. 6 in Atlanta. A full list of dates, including a handful of summer appearances is available at Rae Sremmurd’s website.Catching Up On Music News Powered By The Recording Academy Just Got Easier. Have A Google Home Device? “Talk To GRAMMYs”Read morelast_img read more

How world media covered the declaration of Bangladesh independence

first_imgThe struggle for an independent nation with a distinct identity in the then East Pakistan began long before the declaration of independence of Bangladesh on 26 March 1971, historical evidence suggests.However, the struggle reached its culmination in 1971, especially after the crackdown by the Pakistani army on 25 March.That ‘black night’ saw deaths of more than 10,000 innocent Bangalees, according to the global media reports published the following day. The figures, however, vary in various reports published later on.A day after the brutal killing, Bangabandhu Sheikh Mujibur Rahman, then the undisputed national leader who led the Awami League to election victory in 1970, declared independence, before being arrested. The Mujibnagar government, later in April, made a formal proclamation.The declaration of independence hit headlines of the world media on 27 or 28 March 1971. More than 90 newspapers globally ran stories on the declaration of Bangladesh, according to a compilation titled “Bangabandhu’s declaration of independence through the world media” by Avraneel Yatri.The world media coverage of the massacre and declaration of Bangladesh independence is summarised below:Bangladesh Liberation War e-Archive, also known as Muktijuddho e-Archive, readied a compilation titled “The New York Times Report Archive – 1884-1978” on Bangladesh issues.“Armed Rebellion Reported” was the title of the special report run by The New York Times, on 27 March 1971, with reporting from New Delhi. It reads, “Open rebellion broke out yesterday in East Pakistan, with fighting reported in several cities, and a radio station broadcast proclamation of an independent people’s republic.”The American newspaper alone published more than 7 stories on the Pakistan issues on the day, including more than two special stories.The Times on 27 March (Saturday) ran another story headlined “Leader of Rebels in East Pakistan reported seized” filed by the New Delhi correspondent of The Associated Press.“The Pakistan radio announced today that Sheik (sic) Mujibur Rahman, the nationalist leader of East Pakistan, had been arrested only hours after he had proclaimed his region independent and after open rebellion was reported in several cities in the East,” according to the story.The newspaper used Reuters a story filed from Delhi, titled “Violence reported quelled in a city in East Pakistan”. It reads, “Violence in the riot-torn West Pakistan city Lyallpur was brought under control by the police today and a 24-hour curfew was lifted, the Pakistani radio monitored here, reported.”Another NYT report by Sydney H Schanberg used headline “Artillery Used: Civilians fired on – Sections of Dacca [now Dhaka] are set ablaze” and said, “The Pakistani Army is using artillery and heavy machine guns against unarmed East Pakistani civilians to crush the moment for autonomy in this province of 75 million people”However, a day before, on 26 March, The New York Times published a report with Washington dateline and its title was “US aides rate West Pakistan’s forces as stronger”. NYT correspondent William Beecher wrote there, “Warfare in East Pakistan would find the regular West Pakistani army with superior number of troops and modern weapons, according to the United States analysts here.”“Toll called high: Deaths put at 10,000 – Radio says army in control”, reads a headline of another NYT report which mentioned, “Pakistani government troops supported by artillery and air force jets were reported battling on many fronts today with the forces of Sheik (sic) Mujibur Rahman.”Avroneel Yatri, in “Bangabandhu’s declaration of independence through world media”, compiled news reports carried by at least 90 media outlets globally.The Time (USA) ran a story titled “Pakistan toppling over the brink” that reads, “The government ordered a strict 24-hour curfew in Dacca (sic), with violators shoot on sight.”A report by The Times of India on 27 March with title “Free Bangla Desh (sic)” with a subhead “Heavy casualties in civil war; Pindi troops surrounded in at least six cantonments” reads, “A ‘sovereign independent’ people’s republic of Bangla Desh (sic) was declared by Sheikh Mujibur Rahman today even as President Yahya Khan ordered the army to ‘fully restore the authority’ of his government in turbulent eastern wing.”The Irish Times on 27 March ran a report titled “Declaration of independence by East Pakistan: Fighting Heavy” that reads, “A clandestine radio said last night the East Pakistan has been declared independent and that heavy fighting was going on between East and West Pakistani forces. The radio also said that West Pakistan forces had begun hunting for the East Pakistan leader, Sheikh Mujibur Rahman who went underground after fighting began.”The Michigan Daily on 27 March published a photo circulated by The Associated Press titled ‘Call to Revolution’. A caption of the photo story reads, “Awami League leader Sheik (sic) Mujibur Rahman, speaking to a rally in Dacca (sic) East Pakistan Wednesday, urges support of the East Pakistani nationalist movement. Yesterday, Rahman proclaimed independence for the strife-torn nation.”Irish Independent daily published a report on 27 March with a headline “Blood flows in East Pakistan”.The Bangkok Post on 26 March published a report titled “ Pak Near Civil War” with a subhead ‘East Declares Independence’ that reads “A civil war situation developed in Pakistan as President Yahya Khan outlawed the Awami League of East Pakistan, as its leader, Sheikh Mijubur Rahman proclaimed independence for the province under the name of Bangla Desh (sic).”On 27 March 1971, The Windsor Star published a report titled “Government planes bomb town: Civil war rages in E. Pakistan”.The Transcript, the oldest independent college student newspaper, ran a story titled “Independence proclaimed: Civil war erupts in East Pakistan” on 27 March.Ohio-based The Bryan Times published a story with a headline, “East Pakistan rebels battle of independence”, on 27 March, which reads, “Heavy fighting raged today in East Pakistan where the rebels proclaimed the region independent.”Oregon-based the Bulletin published a report titled “Breakaway action sets off conflict in E., W. Pakistan” that reads, “Civil war broke out today in East Pakistan and East Pakistan leader Sheikh Mujibur Rahman declared his province’s independence from West Pakistan.”St. Petersburg Independent on 27 March ran another story titled “Thousands killed in Pakistan” that reads, “United News of India reported thousands dead in fierce fighting in East Pakistan today and said West Pakistan-dominated army units battling civilians in Dacca (sic), the provincial capital.”Australia’s Sydney-based The Sunday Morning Herald on 29 March ran a story titled “Plunge into chaos”. It said, “It is impossible to know what is happening in East Pakistan. According to Radio Pakistan, President Yahya Khan’s predominantly West Pakistani army is in control of East Pakistan, Sheikh Mujibur Rahman is under arrest…”An Australian newspaper, The Age, published a story titled “Pakistan Tragedy.”Scottish tabloid The Evening Times also published a story that reads “10,000 dead in Pakistan battle” with a shoulder “Mystery of Sheik (sic) Mujibur arrested claim.”The Irish Press ran a story titled “Pakistan in UDI battle” with a shoulder “Thousands reported dead as civil war rages.”last_img read more

TIFFCOM Imagicas Gen8 Pushes Motion Capture

first_img Popular on Variety Takazawa thinks there can be many applications for the data. “We are talking to VR companies and when the technology advances we think our data will be useful for creating VR content,” Takazawa said. He also notes the project will have data on athletes’ movements, and can help track the success, or not, of those athletes, and said that the motion archive will be useful for predicting the success of future athletes by comparing their movements to the archived data.Imagica is also consulting with robotics companies. It believes the Motion Archive data will be useful in creating robots that can move in more natural, human ways. Gen8 (‘Generate”), a team from Japan’s leading film and tech company Imagica Lab, unveiled its Motion Archive project this week. The motion capture-based effort has reached out to artists and athletes and is using the latest visual technology, including 3D imaging, to record, analyze and archive human movement. It demonstrated the technology on the trade show floor of TIFFCOM, the market associated with the Tokyo International Film Festival.Athletes or performers’ movements are recorded with motion capture devices and the body of the subject is scanned in 3D to create a 3D CG image. The image is then inspected with VR devices and archived for long-term data storage.“At first we are capturing traditional Japanese activities like sumo and kabuki,” Tomoya Takazawa, a director of one of the production departments at Imagica told Variety. One of the first big undertakings of the Motion Archive project was to recreate a sumo arena and bout between grand champion Hakuho and former champion Kotoshogiku. The movements of the wrestlers were captured both to have a 3D record of natural sumo moves and to be able to show them from new angles.center_img ×Actors Reveal Their Favorite Disney PrincessesSeveral actors, like Daisy Ridley, Awkwafina, Jeff Goldblum and Gina Rodriguez, reveal their favorite Disney princesses. Rapunzel, Mulan, Ariel,Tiana, Sleeping Beauty and Jasmine all got some love from the Disney stars.More VideosVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9Next UpJennifer Lopez Shares How She Became a Mogul04:350.5x1x1.25×1.5x2xLive00:0002:1502:15last_img read more

Fine dining on the hot seat

first_imgAs the season changes, we need to change our eating patterns and modify our day-to-day routines.Another aspect of our diet that needs to be addressed with the change of season is the freshness of food. Fresh food is light and easily digestible, which is very important, because in summers our digestive capacity reduces as compared to winter. FOODS TO EATSummer is all about fluids and having light meals. Drink lots of fluid -such as water, nimbu pani, buttermilk, lassi, fruit juices and Margarita as you need to keep yourself hydrated. Juices are good but eating the fruit by itself is more beneficial. In case of juices, take freshly squeezed juices without sugar. Try a combination of fruit and veg in your juice like  watermelons, chilled apple, pear, pomegranates, carrot, oranges. Cold soups are also another treat usually reserved for the summer months. Melon and mango soup or cucumber and yogurt soup are the two popular soups of this season. Savory ice creams are  excellent for salads and cold soups. For example – Parmesan or blue cheese ice cream, ceaser dressing ice cream or Gazpacho ice cream are all in trend. Burnt mango is also one of the best coolants and can be utilised in all courses like burnt mango dressing or burnt mango sorbet. Also Read – ‘Playing Jojo was emotionally exhausting’SUMMER COOLERSSorbets are frozen fruit juices that are a much healthier option as compared to ice cream and is coming into trend. Lime chili margarita or frozen mango margaritas are quiet popular this season.Usually three to four meals pattern is best during summer. The easiest snacks during the summers are fruits and vegetables. Make a fruit salad with mango, apple, melons, watermelons etc. Fruits and veggies are packed with powerful nutrients and they help keep you hydrated when the weather heats up. Common Ingredient for this summer are- watermelon, melon, pineapple, mango, beet-root, fruit Palm, bell fruit, lychee, papaya, apricot, plums, peaches, figs, broccoli, cauliflower, cucumber, pumpkin, eggplant, french beans, onions, summer squash, tomatoes, zucchini, olive oil, lemon, tamarind, yogurt and coconut. Also Read – Leslie doing new comedy special with NetflixFOOD NOT TO EATFood which is low in calorific value are excellent in summers. Do not rely on aerated drinks for fluid requirements. Avoid spicy, heavy, fatty/greasy, chips, sodas, pickles, tea, coffee etc. Try to keep your meals light and do not eat too many times a day. Heavy desserts made of khoya, butter, ghee etc should be avoided. The variety of grain should also become lighter, so switch to easier-to-digest grains such as rice, sattu and barley. The requirements of your palate should also keep pace with the change of season.CHILLED TOMATO GAZPACHOIngredientsCucumber (deseeded and skinned) 250 gmsTomato (deseeded) 250 gmsRed pepper (desseded) 150 gmsJalapenos 25Mayonnaise 200White bread 30Salt and pepper 5Almond ice creamCooking cream 160 gmsParmesan cheese 15 gmsEgg yolk nos 1Almond powder 35 gmsChopped almonds 75 gmsFor GarnishBlack olive dust 2 gmsExtra virgin olive oil  2mlMethodBlend all the ingredients together and sieve it through strainer; store it in refrigerator. For icecream – heat cream on double boiler, whisk in yolks until it has emulsified. Add parmesan cheese, almond powder. Freeze and blend in mixer after it is set. Scoop ice cream and pour over chilled soup, garnish with olive dust.  MANGO SEMIFREDOIngredientsEgg Yolk 10Icing Sugar 10 gms Mango Pulp 100 gms Mango Chopped 200 gmsMango Essence 10 mlWhipped Cream 1/2 kgMethodOn a double boiler, beat egg yolk and icing sugar till it fluffs up. Take off the double boiler and let it cool. In another bowl, whisk  mango pulp, mango chopped, mango essence and cream together. Now, fold the mango cream  mixture in the egg yolk and icing mixture by adding the cream mixture slowly without losing muc  fluffiness. Pour it in a ramekin or a dessert bowl and freeze it for 4-5 hrs. Garnish with mango and serve cold.last_img read more

Body of woman found hanging at inlaws residence in Regent Park

first_imgKolkata: Mystery shrouds the death of a housewife whose body was found hanging from a fan inside her in-laws’ house at Regent Park on Thursday.The family members of the victim lodged a complaint at the police station stating that the woman had been murdered by her husband and in-laws who are absconding since the incident had taken place.Police said the victim Nalini Shaw got married to Sanjib Shaw, a resident of Palpara area of Regent Park in February this year. A quarrel broke out between the couple two months after their marriage. It was alleged that accused husband is involved in an illicit love relationship with his sister-in-law and the victim had come to know about the matter. Also Read – Rain batters Kolkata, cripples normal lifeThe victim’s family members told the police that the woman had raised objections several times and urged her husband to call it off. But the accused on the other hand had been mounting pressure on the victim to get divorce. He also gave some papers to the woman asking for her signature. The victim’s father told police that they had paid a few lakh rupees to the accused during the marriage. He said the woman’s farther-in-law called them up on Thursday afternoon saying she locked herself inside a room. When they rushed to the house, they came to know that the victim had been taken to a hospital. They later went to the hospital and found her dead.Police are investigating if the victim had committed suicide after being tortured by the accused or there was any foul play behind her death. On the basis of a specific complaint, police have started a probe.Police are conducting raids to nab the accused. They are also interrogating the other family members of the accused and locals in this connection.last_img read more

Failed students stage sitin protest demand promotion to new class

first_imgKolkata: The authorities of Bethune Collegiate School made it clear on Tuesday that students, who had secured less than pass marks in the Class XI annual examination, will not be promoted to Class XII. A number of students agitated on Monday demanding promotion by pressuring the management to promote them to the next standard. The authorities claimed that most of the students had scored less than 10 percent in the examination.Some of the students, who failed the examination, were accompanied by their guardians to stage a sit-in demonstration in front of headmistress Saswati Adhikary’s room on Monday. They also hurled abuses at some of the teachers and threatened to commit suicide if they are not promoted. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: Mamata”This is a social degradation. The parents are pushing their wards to become doctors or engineers without understanding the fact that every student does not possess the same merit and skill. This has resulted in such chaos in a school like Bethune which is known for its academic excellence,” a senior teacher of the school said. Nearly 25 percent of the students in the school are first generation learners and they have sought admission in the school through lottery system. This system is prevalent in all state schools. Also Read – Lightning kills 8, injures 16 in stateThe agitating students along with their guardians sought intervention from the West Bengal Council of Higher Secondary Examination and complained that the schoolteachers have given less marks than their wards deserved. The council, however, made it clear that the schools have been given free hand when it comes to promotion. It may be mentioned that 119 girls had appeared for the annual examination combining arts and science stream. Out of them, 18 students have failed in two or three subjects. There are even some cases when students have secured 1, 2 and 3 marks in written tests.last_img read more

Still remain Muslim faith is above attire Nusrat slams cleric Twitter says

first_imgKolkata: Actor and newly-elected TMC MP Nusrat Jahan’s was pulled in a controversy on Saturday after a Muslim cleric criticised her for marrying a Jain businessman and wearing a sindoor (vermilion) and bangles. Nusrat Jahan sporting bangles and sindoor while taking oath as Lok Sabha member became a matter of controversy when a Muslim cleric criticised her for marrying a person outside her religion and termed the practice as un-Islamic. “Islam says a Muslim can marry only a Muslim. I have got to know that Nusrat is a film actor and people in the cinema do not care about religious practices. They do what they have to,” said Mufti Asad Quasmi of Madrasa Jamia Sheikh-ul-Hind. He also questioned the parliamentarian’s decision to marry a man belonging to Jainism. However, Nusrat Jahan gave an apt response saying she represents an inclusive India. Taking it to Twitter, the first time parliamentarian who has recently got married, Nusrat Jahan said, “I represent an inclusive India which is beyond the barriers of caste, creed and religion.”(With inputs from DNA)last_img read more

On the Macs 30th Birthday Apple Does Some Horn Tooting

first_imgBeyond that, the company is asking fans to share their stories in a section called “Your first Mac.”Philip Schiller, Apple’s senior vice president of worldwide marketing, even opened up to MacWorld about the anniversary.“Every company that made computers when we started the Mac, they’re all gone,” he said. “We’re the only one left. We’re still doing it, and growing faster than the rest of the PC industry because of that willingness to reinvent ourselves over and over.”That may not seem like much, but for Apple, it’s an uncommon level of candor.Of course, Apple left some of the heavy lifting to websites that were more than happy to publish retrospectives on its behalf. Forbes has this collection of quotes about the machine. Mashableoffered this brief history, which included a mention of the iconic “1984” Super Bowl ad that introduced the Macintosh.The site 9To5Mac created its own timeline of the Mac’s three decades, which you can check out below:Click to Enlarge+ Register Now » Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global Growing a business sometimes requires thinking outside the box. Outside of product announcements and keynote addresses, Apple tends to be a fairly reserved company, to put it lightly. For years, the company has been called tight-lipped and secretive.So the fact that the company added a section to its website Friday marking the 30th anniversary of the Macintosh home computer’s emergence on the market seems uncharacteristic. It isn’t just a timeline and a few words about the computer’s introduction on Jan. 24, 1984, either. There’s a video with gushing interviews with computer experts, teachers, designers, artists, and Moby:center_img January 24, 2014 This story originally appeared on PR Daily 2 min readlast_img read more

Ionic Framework 40 has just been released now backed by Web Components

first_imgIonic Framework today released Ionic Framework 4.0. The release is a complete rebuild of the popular JavaScript framework for developing mobile and desktop apps. Although Ionic has, up until now, Ionic was built using Angular components, this new version has instead been built using Web Components. This is significant, as it changes the whole ball game for the project. It means Ionic Framework is now an app development framework that can be used alongside any front end frameworks, not just Angular. The shift away from Angular makes a lot of sense for the project. It now has the chance to grow adoption beyond the estimated five million developers around the world already using the framework. While in the past Ionic could only be used by Angular developers, it now opens up new options for development teams – so, rather than exacerbating a talent gap in many organizations, it could instead help ease it. However, although it looks like Ionic is taking a significant step away from Angular, it’s important to note that, at the moment, Ionic Framework 4.0 is only out on general availability for Angular – it’s still only in Alpha for Vue.js and React. Ionic Framework 4.0 and open web standards Although the move to Web Components is the stand-out change in Ionic Framework 4.0, it’s also worth noting that the release has been developed in accordance with open web standards. This has been done, according to the team, to help organizations develop Design Systems (something the Ionic team wrote about just a few days ago) – essentially, using a set of guidelines and components that can be reused across multiple platforms and products to maintain consistency across various user experience touch points. Why did the team make the changes to Ionic Framework 4.0 that they did? According to Max Lynch, Ionic Framework co-founder and CEO, the changes present in Ionic Framework 4.0 should help organizations achieve brand consistency quickly, and to give development teams the option of using Ionic with their JavaScript framework of choice. Lynch explains: “When we look at what’s happening in the world of front-end development, we see two major industry shifts… First, there’s a recognition that the proliferation of proprietary components has slowed down development and created design inconsistencies that hurt users and brands alike. More and more enterprises are recognizing the need to adopt a design system: a single design spec, or library of reusable components, that can be shared across a team or company. Second, with the constantly evolving development ecosystem, we recognized the need to make Ionic compatible with whatever framework developers wanted to use—now and in the future. Rebuilding our Framework on Web Components was a way to address both of these challenges and future-proof our technology in a truly unique way.” What does Ionic Framework 4.0 tell us about the future of web and app development? Ionic Framework 4.0 is a really interesting release as it tells us a lot about where web and app development is today. It confirms to us, for example, that Angular’s popularity is waning. It also suggests that Web Components are going to be the building blocks of the web for years to come – regardless of how frameworks evolve. As Lynch writes in a blog post introducing Ionic Framework 4.0, “in our minds, it was clear Web Components would be the way UI libraries, like Ionic, would be distributed in the future. So, we took a big bet and started porting all 100 of our components over.” Ionic Framework 4.0 also suggests that Progressive Web Apps are here to stay too. Lynch writes in the blog post linked to above that “for Ionic to reach performance standards set by Google, new approaches for asynchronous loading and delivery were needed.” To do this, he explains, the team “spent a year building out a web component pipeline using Stencil to generate Ionic’s components, ensuring they were tightly packed, lazy loaded, and delivered in smart collections consisting of components you’re actually using.” The time taken to ensure that the framework could meet those standards – essentially, that it could support high performance PWAs – underscores that this will be one of the key use cases for Ionic in the years to come.last_img read more

Peertopeer video sharing platform BitTorrent has

first_imgPeer-to-peer video sharing platform BitTorrent has launched a multichannel app for live and linear programming at the INTX event in the US.BitTorrent claims that its BitTorrent Live app solves the problems associated with provisioning and latency of live online broadcasting.The platform, which will offer a mix of content spanning news, sports, music, technology and youth culture, will use BitTorrent’s proprietary peer-to-peer live streaming protocol to enable the delivery of live video with, it says, a sub-10 second latency and without the need for expensive CDN distribution and pre-provisioning.“This allows the video stream to remain strong and for the broadcast to be as scalable as traditional Over-the-Air TV,” said the company in a blog posting.BitTorrent Live will include a free tier of programming with linear channels that contain live events.Launch partners include AWE, formerly known as WealthTV, about how wealth is achieved, used and enjoyed, new youth channel Clubbing TV (see separate story), action and adventure channel Heroes TV, conservative-skewed news service Newsmax TV and conservative-skewed political analysis channel OANN, music channel NUsicTV, sports service One World Sports, talk radio service OpenNews TV, hunting and fishing channel Pursuit Channel and technology channel TWiT.tv.The service will also include a raft of channels from SPI International: extreme sports service Fast&Funbox, combat sports channel Fightbox and movie channel Filmbox Arthouse.“Last year Bob Bowman [head of Major League Baseball Advanced Media] told [Wall Street Journal journalist] Walt Mossberg, in regards to the difficulty of large scale live video streaming of sports, declaring, ‘Is that a business model or is that a stunt? I don’t know.’ Well, BitTorrent Live is the platform that can turn large scale live streaming into a business model,” said Erik Schwartz, vice-president of media, BitTorrent Live.last_img read more

Iflix has revamped its user interface with upgrade

first_imgIflix has revamped its user interface with upgraded features designed to focus on the “individual customer experience”.The emerging market SVOD service has added new ‘Channels’, ‘Add’ and ‘Follow’ features that promise a more personalised experience and new ways of discovering content.“We are thrilled to be working with the world’s leading entertainment brands to create exciting new on-demand channels. These are not the channels we grew up with,” said Iflix co-founder and group CEO, Mark Britt.Iflix said its new channels combine “the best of traditional pay television with benefits of on-demand services”, with users able to select their favourite channels and receive recommendations based on their tastes and viewing history.Iflix subscribers can also add TV shows, movies and channels to their Iflix homepage, and use the follow feature to track playlists curated by hundreds of popular influencers and celebrities.“Today represents an incredible milestone for Iflix. This evolution begins to blur the distinction between traditional video-on-demand and traditional pay television,” said Britt.“We are in the golden age of TV for viewers, with thousands of great shows and movies available on demand. For the individual user however, sifting through immense catalogues of programs and finding what you want has become more challenging than ever.“Our new personalisation features now allow us to solve this dilemma by delivering recommendations specifically curated for each local user across our business.”Earlier this month, Iflix completed a US$133 million (€113 million) funding round led by US media giant Hearst.Existing shareholders Sky, Liberty Global, Evolution Media and Jungle Ventures also increased their investments in the firm, and were joined by new backers Singapore-based EDBI and clients of DBS private bank.Iflix has now raised in excess of US$220 million this calendar year and said it will use the latest round to invest in its local content strategy.The company first went live in Asia in May 2015 and in the past year has expanded from four to 20 markets across Asia, the Middle East and Africa. Iflix also has local distribution partnerships with 27 telecoms operators across its territories, which bundle the Iflix service with customers’ mobile and data subscriptions.last_img read more

Government plans to introduce a new safer form of

first_imgGovernment plans to introduce a new safer form of pre-natal testing for Down’s syndrome and other conditions send a message to disabled people that they are “better off being dead than being born”, according to a leading activist.The Department of Health (DH) is believed to be poised to give the go-ahead to non-invasive pre-natal testing (NIPT) across the NHS.Supporters of NIPT claim it is a safer form of pre-natal testing for Down’s syndrome that will eliminate many of the miscarriages caused by pregnant women opting for an invasive amniocentesis.Those who test positive after NIPT will still need to have an invasive test to confirm the diagnosis.A study funded by the NHS National Institute for Health Research (NIHR) found that introducing NIPT instead of more invasive tests for pregnant women with a more than one in 150 chance of having a child with Down’s syndrome would identify 102 more fetuses with the condition, and prevent 25 miscarriages a year.But campaigners say that pregnant women choose to abort about 90 per cent of fetuses identified as having Down’s syndrome, so the new technique would prevent 25 miscarriages but lead to 92 more abortions of fetuses with Down’s syndrome every year.Some academics point to research by Professor Lyn Chitty, at Great Ormond Street Hospital, for the UK National Screening Committee, which found that 30 per cent of women given NIPT decided to carry a Down’s syndrome fetus to term, compared with six per cent under the current system.But even if that proves accurate when NIPT is rolled out, the NIHR research suggests that it would still see an increase of more than 70 babies with Down’s syndrome aborted every year, compared with 25 fewer miscarriages.Disabled activist Simone Aspis (pictured), founder of the training and consultancy organisation Changing Perspectives, said she was “deeply concerned” by the prospect of NIPT being available from the NHS.She said: “Any test that is being used to eliminate disabled people is definitely a form of eugenics.“What message does it send to other people about disabled people and difference – you’re better off being dead than being born.“The more you screen out, the less tolerant people become of people who are different from themselves, and the more the expectation is that you abort a disabled baby.”But she said that introducing such tests also contributes towards “moving the goalposts”, a gradual process in which society is gradually defining more and more people as disabled and therefore expanding the number of fetuses that are suitable candidates to be aborted.Aspis said the key issue was not whether one pre-natal test was better than another because it reduced miscarriages, but “what kind of society do we want?”She said: “We are always going to end up in a system where resources are tight, and there is elitism, so there is going to be the potential for wanting to be eliminating people who are not deemed to be productive. “Someone who is deemed to be averagely productive now will end up [in 10 or 20 years’ time] being labelled with an impairment and therefore be subjected to medical procedures, screening out, and abortion eugenics.“This money could be much better spent in keeping people alive and upholding their fundamental human and civil rights, such as under the UN Convention on the Rights of Persons with Disabilities (UNCRPD).”Last month, the disabled academic Professor Tom Shakespeare offered his opinions about NIPT for BBC Radio 4’s A Point Of View, in which he said that the “major benefit” was that it would lower NHS costs and “more importantly it will also avoid the dozens of miscarriages which result from amniocenteses each year”.He added: “The down side is the potential delay of several weeks before those women at high risk receive a final confirmation of the status of the pregnancy.”He is chairing a Nuffield Council on Bioethics working group, looking at the ethical and social aspects of NIPT, and said in the recording that he was concerned that the NHS puts “a lot of energy and expense into ensuring that these tests are scientifically robust” but less into “achieving balanced information and sufficient counselling” about life with disability.He pointed out that “advocates for people with Down’s syndrome argue that having the condition does not prevent you from having a good life”, and highlighted his own inherited genetic condition, restricted growth, which he passed on to his two children, but which “never stopped any of us flourishing”.He also warned that NIPT was a technology that had been driven by the commercial sector and that providers were “competing to offer more and more information through these blood tests”.Professor Shakespeare said the government’s decision on NIPT was “not just a minor technical upgrade of fetal anomaly screening in the UK” but was instead “a step change”.He said in his BBC recording: “By offering a more accurate and less risky screening test for Down’s syndrome today, we are also taking another step down the path to more widespread testing for conditions in pregnancy tomorrow.”This meant, he said, that there was a need for: better availability of balanced information through genetic counselling in pregnancy; up-to-date online information about conditions; and a “wider debate about what information we are prepared to provide in pregnancy” through genetic testing.But Aspis said that even with improved genetic counselling, would-be parents would still make their decisions on whether to abort their children on how they perceived disability, in a society in which there was “a lot of hatred towards disabled people”.Her concerns about NIPT are shared by the Don’t Screen Us Out campaign, a grass-roots initiative supported by people with Down’s syndrome, families and advocate groups and led by Saving Down Syndrome, which aims to “raise awareness around the discriminatory and eugenic nature of the practice of antenatal screening worldwide”.The campaign has written an open letter to health secretary Jeremy Hunt, warning that introducing NIPT would have “a profound long-term effect on the community of people with Down’s syndrome and further enable the effective ‘screening out’ of those with certain disabilities from the UK population before they are even born”.It called on Hunt to delay the introduction until there is “a full ethical review” of NIPT and the government’s fetal anomaly screening programme, involving people with Down’s syndrome and their families, to ensure NIPT is “consistent and compliant” with the UNCRPD and other human rights obligations. The letter adds: “This must be accompanied with medical reforms to ensure every parent with a disability diagnosis receives balanced information and support to ensure that [NIPT] testing does not lead to the further screening out of people with Down’s syndrome.”A DH spokeswoman said: “We want women to make informed decisions and access safe and appropriate tests.“We are considering this carefully and will make an announcement in due course.”last_img read more

Interview MATT BISOGNO

first_imgSimon Nott is author of:Skint Mob! Tales from the Betting RingCLICK HERE FOR MORE DETAILS MATT BISOGNO (part 3 of 3)In the third and final part Matt talks about fairness to punters and bookmakers plus his hopes for the HBF in the future. Interview: MATT BISOGNO Matt became intoxicated by horseracing as a young man, then worked in betting shops while studying for his degree. After a few non-racing roles he took a deep breath then a plunge setting up GeeGeez.co.uk which has proven successful since its launch. He has also had success as an owner as head of several syndications. Matt has recently taken over as the chair of the Horseracing Bettors Forum, a voluntary body that campaigns for the rights and interests of punters. Meeting Matt Bisogno.MATT BISOGNO (part 1 of 3)Chair of the Horseracing Bettors Forum and owner of geegeez.co.uk Matt Bisogno talks about his early years getting into horseracing, working in betting shops en-route to the formation of his website and syndicates. He also talks about the work of the HBF so far and answers some of the criticism levelled towards them from some quarters.center_img MATT BISOGNO (part 2 of 3)Chair of the HBF Matt Bisogno concedes he should have chosen his words on social media better when describing some racecourse bookmakers. He talks the future of on-course bookmakers, educating punters and how racecourse’s own betting operations can mislead punters.last_img read more

Irish PM says Brexit undermines Good Friday Agreement

first_imgIreland’s Taoiseach Leo Varadkar hosts a ‘Getting Ireland Brexit Ready’ workshop at the Convention Centre in Dublin, Ireland on October 25, 2018. (Reuters) London best pest control “Brexit has undermined the Good Friday Agreement and is fraying the relationship between Britain and Ireland,” he told Irish state broadcaster RTE.The border between Ireland and Northern Ireland after Brexit has been one of the major sticking points in Britain’s negotiations to leave the European Union in March next year.“Anything that pulls the communities apart in Northern Ireland undermines the Good Friday Agreement, and anything that pulls Britain and Ireland apart undermines that relationship,” Varadkar added.Ties between Britain and Ireland have been tested over the last two years with Ireland a key player on the opposite side of the Brexit negotiating table to Britain. Arguments over how to manage the the border between EU-member state Ireland and British-ruled Northern Ireland have threatened the talks.Britain and Ireland are co-guarantors of the 1998 peace deal that ended 30 years of sectarian violence in Northern Ireland and introduced devolved government.However the power-sharing executive has not met for almost two years following a breakdown between Irish nationalist and pro-British unionist politicians.Source: Reuters Brexit has undermined the Good Friday Agreement which ended thirty years of violence in Northern Ireland, Irish Prime Minister Leo Varadkar said on Saturday. Britain and Ireland are co-guarantors of the 1998 Good Friday Agreement, which ended 30 years of sectarian violence between between Irish nationalists and pro-British unionists in Northern Ireland.last_img read more

Kristen Stewart CoWrote an Academic Paper About Artificial Intelligence

first_img Kristen Stewart — the actress best known for Twilight — has co-written a paper on machine learning.The paper outlines the use of neural style transfer in Stewart’s directorial debut, Come Swim, which is about to premiere at Sundance Film Festival. Neural style transfer turns normal images into impressionist art, and is used by popular photo app Prisma.The paper, first spotted by Quartz, is co-bylined with Adobe research engineer Bhautik J. Joshi and producer David Shapiro. It was published yesterday on ArXiv, a repository run by Cornell University for scientific papers that are not yet peer-reviewed.Come Swim describes itself as “half realist, half impressionist portraits” of one man’s day. A teaser video for the short film is shot in a surreal style.According to the paper, the project was based on an impressionistic painting of Stewart’s, which shows a man waking up.Image credit: Starlight Studios/Kristen StewartThe paper outlines the repetitive technical process of trying to replicate the feel of the painting on-screen. Here’s a sample:”The painting itself evokes the thoughts an individual has in the first moments of waking (fading in-between dreams and reality), and this theme is explored in the introductory and final scenes where this technique is applied. This directly drove the look of the shot, leading us to map the emotions we wanted to evoke to parameters in the algorithm as well as making use of more conventional techniques in the 2D compositing stage.”The response to the paper has been positive from the academic community, if slightly bemused.I used to tell Twilight jokes in my Intro to AI class. I take it all back.— Mark Riedl ? (@mark_riedl) January 19, 2017Kristen Stewart co authored a machine learning paper. Now we can calculate her Erdos number https://t.co/EhEKaJGWbD— Wil Chung (@iamwil) January 20, 2017 2 min read Artificial Intelligence January 20, 2017 –shares Add to Queue Shona Ghosh Kristen Stewart Co-Wrote an Academic Paper About Artificial Intelligence This story originally appeared on Business Insider Senior Reporter Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Register Now » Next Article Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Kristen Stewart Image credit: Neilson Barnard/Getty via BI The paper outlines the use of neural style transfer in Stewart’s directorial debut, ‘Come Swim,’ which is about to premiere at Sundance Film Festival.last_img read more

Here Are the Origins of 10 Tech Terms You Use Every Day

first_img Add to Queue Entrepreneur Staff March 30, 2018 –shares Image credit: Stanislaw Pytel | Getty Images Apply Now » Here Are the Origins of 10 Tech Terms You Use Every Day Nina Zipkin Staff Writer. Covers leadership, media, technology and culture.center_img 2019 Entrepreneur 360 List Did you know that Thomas Edison used the term ‘bug’? The funny thing about language is how words and phrases seep in everyday use without anyone realizing exactly where they came from. As ubiquitous as technological devices are in our daily lives, so is the vocabulary that is attached to the innovation that made them possible.But who invented the words that have become so commonplace? Read on to find out.BugIf you have referred to a tech problem as a bug, you can thank pioneers including Thomas Edison and U.S. Navy Rear Admiral Grace Hopper. Edison used the term in some correspondence about the development of the telephone in 1878, and Hopper, one of the inventors of the electronic computer in the 1940s, is believed to have coined the term when she discovered an actual moth trapped inside one of her prototypes.CrowdsourcingIf you’ve used a site such as Yelp or TripAdvisor to narrow down your choice of restaurant or lodging, you’ve taken advantage of crowdsourcing. But the term wasn’t invented until 2006, in an article in Wired by a writer and editor named Jeff Howe.Related: How Crowdsourcing Is Shaping the Future of EverythingMouse A Stanford engineer named Doug Engelbart invented the computer mouse as a prototype in 1961. But why it was called a mouse is a little bit of a mystery. According to the Computer History Museum, Engelbart couldn’t remember who was responsible for calling it a mouse. The name served as a shorthand to describe the device, which at the time had a long wire that made it look like a rodent with a tail.Open Source Open source software, which comes with code that anyone can access and improve or change, wasn’t always called “open source.” Scientist Christine Peterson came up with the term in 1998 at the Foresight Institute, a nonprofit think tank dedicated to nanotechnology and advances in AI. Today, companies such as Amazon, Google and Microsoft all use open source as a part of their business models.SpamWhile it’s hard to pin down the one person who decided that junk mail should be called spam, internet entrepreneur and author Brad Templeton says that the famous Monty Python viking spam sketch, which made the lunch meat synonymous with unrelenting repetition, was adopted by the users of very early chat rooms in the late 1980s to describe the process of overwhelming a computer with data to crash it.Blog In 1997, a writer named Jorn Barger created a site where he shared links with readers called Robot Wisdom WebLog, with WebLog short for logging the web. In 1999, a programmer named Peter Merholz shortened the phrase even further to blog, which started gaining traction by users of platforms such as LiveJournal and WordPress.Related: How to Make Over $1,000 a Month by BloggingBig Data While the definitive source of the term big data — which is used describe a collection of analytics that companies use to predict customer behavior — is a little fuzzy, according to some digging done by New York Times reporter Steve Lohr, the person responsible for its popularization is a man named John Mashey, a computer scientists who was VP and chief scientist at company called Silicon Graphics in the early 1990s and 2000s.Meme While we share memes every day, the word actually didn’t get its start online, but in a different field of science. It was coined by Richard Dawkins, the famous British evolutionary biologist who was a professor at the University of Oxford. He introduced the word in his 1976 book The Selfish Gene, and used it as a way to describe how trends and societal practices catch on and become popularized.Internet of Things The phrase is used to describe a system of everyday items that are built to be equipped with wi-fi capabilities. Think of the setup of a smart home, with for example, a refrigerator that knows when to order new groceries. Kevin Ashton, a British author and scientist who is an expert in the field of sensing technology, coined the term in 1999 when he was working at Proctor & Gamble to help improve supply chain communication systems. He is also the founder of the Auto-ID Lab at MIT.Unicorn If you were wondering why crazy successful tech startups — ones that are valued at more than $1 billion — are called unicorns, you can thank Aileen Lee, a venture capitalist and the founder of the firm Cowboy Ventures. Why unicorn? Because of the mythic rarity of a startup reaching that milestone. Not something you see in the wild every day, if at all.   Next Article The only list that measures privately-held company performance across multiple dimensions—not just revenue. 4 min read Technologylast_img read more

Why Nintendo is Playing Down Pokémon Gos Earnings Impact

first_img Autoplay: On | Off Summer is here and there are some great looks this season for women of all shapes and sizes. Check out the hottest styles for hourglass, rectangle and pear shaped women. Next Article A Petition Is Coming ? for a ‘Game of Thrones’ Final Season Do-Over Sophie Turner Talks Dark Phoenix, Co-Star Jessica Chastain and GoT Register Now » Heat Snapshot Up Next: Figure Out Your Family Tree Just in Time For Father’s Day Economy adds 75K jobs in May A Petition Is Coming ? for a ‘Game of Thrones’ Final Season Do-Over July 25, 2016 Summer Beauty Survival Must-Haves Summer Beauty Survival Must-Haves –shares North Carolina superintendent says new app can help reduce violence in schools Airbnb Wants to Take You on an All-Inclusive Adventure The requested video is no longer available Nintendo Sophie Turner Talks Dark Phoenix, Co-Star Jessica Chastain and GoT Airbnb Wants to Take You on an All-Inclusive Adventure 2020 Toyota Camry BACK 2 Delicious Summer Entertaining Ideas Swimwear Styles for All Shapes and Sizes Former world paragliding champion Rémy soars over Pyrenees Economy adds 75K jobs in May A Safe Way to Get Rid Of Bugs in Your Home DiCaprio, Pitt want to team up again after Tarantino hit Cannes: ticketless festival-goers seek seats for films Figure Out Your Family Tree Just in Time For Father’s Day Delicious Summer Entertaining Ideas Photo of solider placing flag at Tomb of Unknown Solider goes viral Justin Bieber Launches Plant-Based Deodorant Memorial Day Weekend Heat Wave Could Smash May Records A Safe Way to Get Rid Of Bugs in Your Homecenter_img Figure Out Your Family Tree Just in Time For Father’s Day Free Webinar | July 31: Secrets to Running a Successful Family Business Albany Steps Closer to Releasing Trump’s State Tax Returns After Assembly Vote Why Nintendo is Playing Down Pokémon Go’s Earnings Impact 2 Musts for Tackling Allergy Season Congress Is Back as President Trump Heads to the UK IndyCar Beefing Up Business as Indy 500 Approaches Saint Laurent dazzles with men’s collection on Malibu beach Embed HBO’s ‘Chernobyl’ Phenomenon How Human Behavior is Hurting Animals and What We Can Do to Protect Them Privacy Policy   |   Terms of Use A LifeMinute with Ryan Seacrest 2020 Ballots May Have a New Box to Check ? Vice President A LifeMinute with John Lithgow: The Actor Discusses His Latest Projects Sunlight Shines on Grand Canyon Turning Up the Heat in the Southeast for Holiday Weekend Memorial Day Weekend Heat Wave Could Smash May Records Figure Out Your Family Tree Just in Time For Father’s Day Add to Queue Rock and Roll Hall of Fame Guitarist Don ‘Fingers’ Felder Releases New Album 2 Musts for Tackling Allergy Season Beyond Meat Earnings Are Beyond Analyst Expectations US Navy: Russian destroyer almost collided with cruiser in the Philippine Sea Figure Out Your Family Tree Just in Time For Father’s Day Father’s Day is such a special moment for the whole family to come together and spend quality time with one another – and those are moments dad will cherish. What better way for dad to connect with his loved ones than learning about his family’s stor Lifeminute tv IHOP Sees Explosive Growth in To-Go Sales Reuters New York takes aim at skyscrapers’ sky-high energy usage Southern Charm’ Star Talks New Season This story originally appeared on Reuters Shares in Nintendo Co. tumbled as much as 18 percent on Monday after the company said Pokémon Go would have a limited impact on its earnings — their biggest setback so far after a huge run-up on the smash-hit game.The Kyoto-based gaming company, which is due to report first-quarter results this week, surprised markets with a statement on Friday that income garnered through its 32 percent stake in affiliate Pokémon Company, which owns the licensing rights, would be limited and that it did not plan to revise its earnings outlook for now.Recording its biggest decline since October 1990, the stock ended down 17.7 percent, or by 5,000 yen — the daily limit allowed.But some market players said Nintendo was being disingenuous, adding that there were few expectations of upward revisions to its profit targets so early after the game’s launch and that it was clear the game would be key to earnings.”The market has overreacted to the Nintendo statement,” said David Gibson, a senior analyst at Macquarie Securities Group, noting the game in Japan had broken records with 10 million downloads in one day.”I believe that Pokémon Go will be material in the company’s earnings given the current trends for the game.”Pokemon GO’s success has triggered massive buying in Nintendo shares and even with Monday’s decline, the shares are still up some 60 percent compared with levels prior to the game’s July 6 launch in the United States, Australia and New Zealand, adding nearly $12 billion in market value.Yasuo Sakuma, portfolio manager at Bayview Asset Management, said he still saw the company’s shares as cheap given the potential for Nintendo to reap rewards from other strong character franchises as it forays deeper into mobile gaming.”Nintendo is well-placed to boost its earnings with its other characters, such as Super Mario and Zelda and their potential is unknown,” he said.Pokémon Go is Nintendo’s first venture into mobile gaming as the company had until recently been keen to protect its console business from cannibalization.In addition to its stake in Pokémon Company, Nintendo has an undisclosed holding in Niantic Inc. — the game’s developer, which was spun off from Google.It is also expected to benefit from sales of Pokémon Go Plus — an accessory that alerts players to nearby Pokémon so that they don’t have to always be looking at their smartphones. Nintendo said, however, that sales of the device have already been factored into its earnings outlook.Nintendo, which reports earnings on Wednesday, has forecast a 37 percent rise in operating profit to 45 billion yen ($425 million) in the year to March. While it is expected to see upside from Pokémon Go it will also have to contend with a strong yen which eats into the value of earnings garnered abroad.Seven analysts’ estimates that have been revised since the game’s launch range from 36 billion yen to 60 billion yen.($1 = 106.2400 yen)(Reporting by Junko Fujita; Additional reporting by Ayai Tomisawa and Chang-Ran Kim in Tokyo and Anshuman Daga in Singapore; Editing by Edwina Gibbs) Cannes: ticketless festival-goers seek seats for films 3 min read Learn how to successfully navigate family business dynamics and build businesses that excel.last_img read more

UserIQ Names Tyler Winkler as CEO

first_img AcquisitionBIP CapitalMarketingMarketing TechnologyNewsTyler WinklerUserIQ Previous ArticleIntermap’s NEXTMap Elevation Data and Analytics Now Included on IgniteNet’s LinqPath Online Planning Tool for 5GNext ArticleDirectLync Shakes Up Small Business Marketing with New Digital Marketing Platform Former VP at SecureWorks Takes the Helm at Fast-Growth Startup Focused on Customer SuccessUserIQ, an innovative customer success platform helping businesses align around user needs, announced that its board of directors has appointed industry veteran Tyler Winkler as CEO. Winkler was formerly the VP of Global Sales & Marketing at SecureWorks, where he played a key role in the company’s rapid growth leading up to its 2011 acquisition by Dell for $650 million and 2016 IPO.UserIQ helps businesses realize the full value of customer success by equipping teams with the product analytics, customer insights, and user engagement tools to fight churn, grow the account, and align the entire business around users’ needs. The company recently raised $3.6 million in a funding round led by BIP Capital, which has participated in multiple funding rounds.With customer experience predicted to overtake price and product as a key brand differentiator by 2020, the customer success industry is primed for growth. A report by the Temkin Group found that companies that earn $1 billion annually can expect to earn, on average, an additional $775 million within three years of investing in customer experience.Marketing Technology News: Philo Reveals Connected TV Ad Platform to Reach Latest Generation of TV Lovers“The next evolution of customer success will involve helping companies orient their entire business around their customers’ needs and goals,” said Winkler. “I’m excited to be part of an innovative company like UserIQ with solutions that can help businesses truly adopt a customer success mindset so they in turn can be successful.”“There are similarities between the early years of SecureWorks and UserIQ in terms of company size and sheer market potential, so we’re very pleased that Tyler is taking on the CEO role,” said Mark Buffington, BIP Capital CEO and a member of UserIQ’s board of directors. “Tyler’s executive leadership and proven track record of rapidly scaling technology companies will be a huge asset as UserIQ begins its next phase of growth.”Marketing Technology News: Data Privacy: Balancing Personalization and Security in the Age of TransparencyDuring his 15-year tenure at SecureWorks, Winkler was highly instrumental in growing the company from $800,000 in revenue to become the leader in global managed security services with revenue of $450 million in 2016. Winkler also led SecureWorks’ global expansion and large-scale restructuring following its acquisition by Dell, including the simultaneous enlargement of its sales operations, marketing, channel, and business development functions. He holds a bachelor’s degree in Business Administration, Management, from Towson University.Marketing Technology News: HipChat Founders Launch Swoot, a Social Podcast App UserIQ Names Tyler Winkler as CEO PRNewswireApril 24, 2019, 4:02 pmApril 24, 2019 last_img read more

Study Targeting specific genomic mutation in breast cancer improves survival

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Oct 22 2018Targeting a common mutation in patients with hormone receptor positive (HR+) HER2 negative (HER2-) advanced breast cancer with the alpha-specific phosphatidylinositol-3-kinase (PI3K) inhibitor alpelisib significantly improves progression-free survival, according to late-breaking results reported at ESMO 2018.”Alpelisib is the first drug to show a benefit in a genomic subgroup of breast cancer patients,” said lead author Fabrice André, oncologist and Professor of Medical Oncology at the Institut Gustave Roussy, Villejuif, France. He explained: “We have had HER2-targeted drugs – targeting the HER2 protein – but, until now, the use of tumor genomics has not really entered the practical care of breast cancer, unlike melanoma or lung cancer.”About 40% of patients with HR+ breast cancer have PIK3CA mutations, activating the PI3 kinase pathway leading to cancer progression and resistance to endocrine therapy. Alpelisib (BYL719) is an oral PI3K inhibitor that is alpha specific. “The alpha isoform of PI3-kinase is the one that is mutated in breast cancer. Previous PI3K inhibitors targeted all four isoforms so there were a lot of toxicities,” noted André. A previous phase 1 trial with alpelisib showed promising preliminary efficacy and manageable safety profile.The SOLAR-1 trial randomized 572 postmenopausal women or men with HR+, HER2- advanced breast cancer; 341 had PIK3CA mutations when tumor tissue was tested. The patients had good performance status (Eastern Cooperative Oncology Group (ECOG) status of ?1) and had received one or more prior lines of hormonal therapy but no chemotherapy for advanced breast cancer. They had not previously received fulvestrant, or any PI3K, Akt or mTOR inhibitor, and were not on concurrent anticancer therapy.Patients were randomized to oral alpelisib (300 mg/day) or placebo plus intramuscular fulvestrant (500 mg every 28 days and on days 1 and 15 of treatment cycle 1). The primary endpoint was locally assessed progression free survival (PFS) in patients with PIK3CA mutations, detected in tumor tissue.Results showed the PFS was nearly twice as long in patients with PIK3CA mutations randomized to alpelisib compared to the placebo group. The median PFS was 11.0 months in the alpelisib arm compared to 5.7 months in the placebo group (hazard ratio 0.65, 95% confidence interval [CI] 0.50 to 1.25, p=0.00065) at a median follow-up of 20.0 months.Just over one-third (36%) of patients with measurable PI3KCA-mutated advanced breast cancer (n=262) responded to alpelisib plus fulvestrant, while the overall response rate in the placebo/fulvestrant group was 16% (p=0.0002). The secondary endpoint of locally assessed PFS in patients without PI3KCA mutations did not meet the predefined proof of concept endpoint (HR0.85, 95% CI 0.58-1.25, median 7.4-5.6mo).Related StoriesNew study to ease plight of patients with advanced cancerTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerCancer killing capability of lesser-known immune cells identifiedAndré said: “Alpelisib offers the potential for increased life expectancy in patients with HR+ HER2- advanced breast cancer with PI3KCA mutations.” But he cautioned: “For now, the follow-up is short so we cannot say whether there is a long-term survival benefit. But alpelisib increased progression-free survival and that will hopefully translate to improvement in outcome.”Commenting on the study for ESMO, Prof. Angelo Di Leo, Head of the Department of Medical Oncology, Hospital of Prato, Italy, said: “This is the first trial to show a clinically relevant benefit with a PI3K inhibitor combined with endocrine therapy in patients with HR+ HER2- advanced breast cancer with PIK3CA mutations.”Di Leo added: “The next critical step will be to understand when, and how, this compound should be incorporated into the current treatment algorithm – upfront, in combination with endocrine therapy and a CDK4/6 inhibitor, or sequentially, after disease progression on the combination of endocrine therapy and a CDK4/6 inhibitor.” He cautioned that a limitation of the study was that only a modest number of patients were pre-treated with CDK4/6 inhibitors, which have become a new standard of care in this setting.The most frequent side-effects with alpelisib were hyperglycaemia, which André said could be managed with metformin, nausea, decreased appetite and rash. He said: “There is no life-threatening toxicity or major toxicity that would be expected to affect quality of life. This is good because alpelisib is a drug that is supposed to be given before chemotherapy.”Considering the wider implications, André said: “This study opens the door for clinical genomics for breast cancer as the first study to show that treatment based on a patient’s tumor genomic profile – specifically PI3KCA mutation – can improve the outcome.” He predicted: “These results will have a major impact for practice because we have to implement genomic testing for breast cancer.”Di Leo agreed: “If PI3K inhibitors become a treatment option for patients with advanced breast cancer, assessing PIK3CA mutations using plasma samples (liquid biopsies) will become standard of care, with the considerable advantage of this being a non-invasive procedure.” Source:https://www.esmo.org/Press-Office/Press-Releases/SOLAR-aplelisib-fulvestrant-breast-cancer-Andrelast_img read more

Russian researchers develop novel combined action drug for cancer diagnostics and treatment

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Dec 4 2018Russian researchers announced the development of a combined action drug based on ionizing radiation and bacterial toxin. Their total effect appeared to be 2,200 times stronger compared to that exerted by the radiation and toxin, separately. The drug affects tumor cells selectively providing better diagnostics and treatment of malignant tumors. These advances were reported in an article published in the Proceedings of the National Academy of Sciences.Chemotherapy is widely used for treatment of cancerous diseases. However, it is associated with severe side effects (hair loss, nausea, loss of appetite, oedema, anemia, memory disorders, and so on) as the drugs affect the body in total and are accumulated throughout normal tissues. Moreover, the chemotherapy often requires repeated drug administration to overcome tumor propensity to relapse. A perfect anti-cancer drug should provide a powerful impact to all tumor cells at once to prevent their recovery.The combined therapy proposed and realized by the Russian scientists appeared to be successful. “Just like modern armies deploy tanks, foot troops, and artillery, we also fight tumors using several mechanisms at once: ionizing radiation and a strong toxin of bacterial origin,” says Andrey Zvyagin, head of the Department of Biomedical Engineering at the Institute of Molecular Medicine, Sechenov University.The drug developed by the scientists consists of a nanoparticles, as the core, with embedded radiopharmaceutical agent (a source of ionizing beta-radiation), and a highly toxic toxin derived from bacterium Pseudomonas aeruginosa. The nanosized drug core is decorated with polymer to render the nanocomplex water miscible and biologically amiable and coupled with biological molecules, which represent the toxin fused with a targeting biomolecule by genetic engineering methods. The radiopharmaceutical agent is well secluded inside the nanoparticle and guarantees its side-effect-free targeted action to tumor cells. Blood vessels that feed the tumor have pores through which the drug enters the tumor from the blood flow. The targeting biomolecule binds itself with cancer cells causing them to accumulate in the primary and metastatic tumors. The radiopharmaceutical agent is able to affect the cells both in immediate proximity to the nanoparticles and up to 1 cm from them, providing for efficient therapy of considerable tumor masses. The toxin blocks the synthesis of proteins in the cells preventing them from restoration and dissemination.The new drug was tested both on cells and laboratory animals: breast cancer (the most widely spread type of cancer in women) was grafted on a laboratory mouse, and after that the tested drug was administered to it. In experiments on cells, the effect of the combination was 2,200 times stronger than the effect from the separate use of its components. The efficiency of combined therapy was confirmed by experiments on laboratory mice. The drug not only treats, but also facilitates visualization of the tumors, which makes it a diagnostical tool. The area of medicine that combines diagnostics and treatment is called theranostics. Source:https://www.sechenov.ru/last_img read more